RENEFIL ULTRA PLUS

Description

Name: RENEFIL ULTRA PLUS
Manufacturer: BMI Korea
Active Substance(s): POLYDEOXYRIBONUCLEOTIDE, HA, LIDOCAINE

RENEFIL ULTRA PLUS is a hybrid dermal filler combining cross-linked hyaluronic acid (HA) and sodium polynucleotide (PN) with lidocaine. It is specially designed for deep volumizing and contouring, offering both immediate structural support and longer-term skin regeneration benefits.

• Type: Biphasic-monophasic hybrid filler (HA + PN + Lidocaine)

• Purpose: Deep dermal and subcutaneous injection for facial volume restoration

• Form: Supplied as a 1 mL prefilled sterile syringe with 2 needles

RENEFIL ULTRA PLUS is optimized for deep correction, offering high elasticity, cohesiveness, and shape retention. It is ideal for lifting sagging tissue, restoring volume, and reshaping the mid to lower face.

• Delivers strong lift capacity with high elasticity

• Provides long-lasting volume and structural definition

• Stimulates collagen production for sustained skin quality

• Easy, smooth injection with low extrusion force

• Suitable for areas with severe volume loss or strong tissue resistance

Each unit of RENEFIL ULTRA PLUS contains a clinically tested combination of active ingredients tailored for volume and regenerative effect.

• Cross-Linked Hyaluronic Acid (HA) – 20 mg/mL

  • Adds bulk and structural volume

• Sodium Polynucleotide (PN) – 1.875 mg/mL

  • Enhances skin texture and supports tissue healing

• Lidocaine Hydrochloride – 0.3% (3 mg/mL)

  • Provides comfort during injection

This filler is intended for deep facial volume restoration and contour enhancement. It is especially useful for correcting advanced volume loss, hollow features, and facial asymmetries.

• Correction of deep nasolabial folds, marionette lines, and pre-jowl sulcus

• Contouring the chin, jawline, and zygomatic arch

• Restoration of temple volume and lifting the mid-face

• Improves facial symmetry and rejuvenates aging contours

RENEFIL ULTRA PLUS is injected into the deep dermis or subcutaneous plane, depending on the desired aesthetic effect and anatomical site.

• Commonly treated areas include:

  • Cheeks (malar zone)

  • Chin and pre-jowl area

  • Jawline definition

  • Temples and zygomatic bone

• Ideal injection depth: Deep dermis to subcutaneous layer

• Recommended needle: 27G, included in the packaging

The product is prefilled and sterile. No reconstitution or mixing is needed.

• Each box contains:

  • 1 mL syringe

  • 2 sterile 27G needles

• Product should be used under aseptic conditions

• Do not combine with other injectables in the same syringe

• Use immediately after opening

RENEFIL ULTRA PLUS should be administered by licensed medical professionals with experience in structural filler techniques.

• Inject using linear threading, bolus, or fanning methods

• Target deep dermis or subcutaneous fat layer

• Dosage depends on area and extent of correction

  • Typical per-area range: 0.5–1.0 mL

• Avoid overcorrection; product provides a strong lifting effect

To ensure product stability and safety, follow these storage guidelines:

• Store at 2°C to 25°C (36°F to 77°F)

• Keep away from direct sunlight and freezing temperatures

• Do not use if the packaging is damaged

• Single-use product—discard any remaining material after treatment

The product is not suitable for all patients. Avoid use in the following conditions:

• Known allergy to HA, PN, or lidocaine

• Autoimmune disease, bleeding disorders, or immunocompromised states

• Pregnant or breastfeeding individuals

• Active skin infections, such as acne or herpes, at injection sites

• History of keloid formation or skin hypersensitivity

Proper administration and patient screening are essential to avoid complications.

• Do not inject into blood vessels—risk of embolism or necrosis

• Avoid use in areas previously treated with permanent fillers

• Ensure anatomical knowledge to avoid nerve or vascular injury

• Do not combine with chemical peels, laser, or microneedling in the same session

• Suitable only for use by trained medical professionals

Patients should be informed of basic aftercare to enhance results and minimize risks.

• Avoid touching, massaging, or applying pressure for 24 hours

• Refrain from makeup, alcohol, and strenuous activity for 24 hours

• Avoid extreme heat or cold, including sun exposure, saunas, and cryotherapy for 3 days

• Use cold compress for minor swelling or bruising

• Report any signs of infection or vascular occlusion immediately

While generally safe, some patients may experience mild to moderate side effects.

• Common:

  • Swelling, redness, tenderness, bruising, itching

• Uncommon:

  • Lump formation, asymmetry, transient nodules

• Rare:

  • Allergic reactions, vascular occlusion, tissue necrosis

• Side effects typically resolve within 2–7 days

Patient suitability must be assessed before treatment.

• Approved for use in adults 18 years and older

• Ideal for those with visible facial volume loss or sagging

• Not recommended for patients with chronic illnesses, skin conditions, or immunosuppression

• Requires a full medical history, including medications and allergies

For lasting results, patients should follow a structured treatment plan based on their goals.

• Results last approximately 12–14 months, based on area and metabolism

• Maintenance treatments can be done every 9–12 months

• Repeat sessions may be needed for progressive correction or symmetry adjustment

RENEFIL ULTRA PLUS is developed by BMI Korea Co., Ltd., under strict quality standards. It is CE-certified and manufactured following EN ISO 13485 regulations.

• Manufacturer: BMI Korea Co., Ltd., Jeju, South Korea

• CE Certificate: No. 2020-MDD/05-095

• Patent-protected hybrid formula using cross-linked HA + PN

• Registered in multiple global markets including USA, EU, Korea, China, and Russia

What’s the main use of RENEFIL ULTRA PLUS?
It is designed for deep volume restoration and facial reshaping.

How long does it last?
Clinical studies show effects lasting 12–14 months, with high shape retention.

Is the injection painful?
It includes 0.3% lidocaine, making it more comfortable than standard fillers.

Can it be used with other treatments?
Yes, but space out sessions. Avoid combining with energy-based devices or peels on the same day.

Is it reversible?
Yes, as a HA-based filler, it can be reversed using hyaluronidase if needed.