IGF-1 LR3 1mg

Description

Strength: 1mg
CAS: 946870-92-4
Chemical Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
Molecular weight: 9117.60 g/mol
Peptide Sequence: MFPAMPLSSL–FVNGPRTLCG–AYGGSCASFR–RGFYFNKPTG–YGSSTKKAYG–NNYRRHPLLK–PPIKSAQG
Synonyms: Long R3-IGF-1, M9L22Y19H9, 143045-27-6, Long-(arg3)insulin-like growth factor-i, IGF-I analog
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

The IGF-1 peptide, specifically IGF-1 LR3 (Long Arg³ insulin-like growth factor-1), is a synthetic analogue of native human insulin-like growth factor-1 developed for controlled laboratory research. Laboratories that buy IGF-1 peptide or order IGF-1 peptide materials reference IGF-1 LR3 for experimental studies examining IGF signaling behavior and binding-protein interactions in research systems.

IGF-1 LR3 consists of 83 amino acids and has a molecular weight of 9117.60 g/mol. Compared with endogenous IGF-1, which contains 70 amino acids, this analogue includes a 13-amino-acid N-terminal extension and a single amino acid substitution at position 3. These structural modifications reduce interaction with insulin-like growth factor binding proteins (IGFBPs), particularly IGFBP-3, a property examined in comparative laboratory studies.

• CAS Number: 946870-92-4

The muscle growth and performance peptide is supplied as a lyophilized powder in 1 mg glass vials, commonly produced at ≥95–99% purity as verified by analytical testing, and intended exclusively for laboratory research use.

• Chemical Identity: Modified IGF-1 analogue (IGF-1 LR3)
• Peptide Sequence: MFPAMPLSSL–FVNGPRTLCG–AYGGSCASFR–RGFYFNKPTG–YGSSTKKAYG–NNYRRHPLLK–PPIKSAQG
• Chemical Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
• Purity: Commonly reported at ≥95–99%, verified by analytical methods
• Format: Supplied as a lyophilized powder in sterile glass vials
• Binding characteristics: Reduced interaction with IGF binding proteins compared with native IGF-1
• Research scope: Studied in laboratory models examining IGF receptor signaling and cellular response patterns

For laboratory research use only.

IGF-1 LR3 has been examined in laboratory research as a modified IGF-1 variant evaluated for its interaction with the IGF-1 receptor under controlled experimental conditions. Due to reduced IGFBP binding, the peptide is used in research systems to explore IGF signaling behavior with altered binding-protein modulation.

Research applications include:

• IGF receptor signaling studies in cell culture models
• Comparative binding investigations assessing IGF-1 variants and IGFBP interactions
• Muscle, adipocyte, and developmental cell systems used for experimental signaling analysis
• Preclinical growth-factor research models evaluating short-term cellular response markers

All applications described reflect controlled laboratory research contexts and do not imply clinical or therapeutic use.

Reported research use of IGF-1 LR3 varies across experimental designs, model systems, and analytical endpoints. In in vitro studies, the peptide is typically evaluated at nanogram-per-milliliter concentrations, with working ranges adjusted based on cell type and assay requirements.

Preclinical animal research has explored experimental infusion and exposure protocols to assess IGF-related signaling markers, cellular response patterns, and other assay-specific molecular readouts. These observations are derived exclusively from controlled laboratory and animal research environments and do not establish safety, efficacy, or clinical relevance.

Researchers who order IGF-1 peptide materials are expected to define experimental parameters appropriate to their specific model systems.

• Store lyophilized vials at –18 °C to –20 °C, protected from light and moisture
• Maintain vials in a desiccated environment when not in use
• Reconstitute only with sterile water, PBS, or appropriate laboratory media using aseptic technique
• Only expose at room temperature during shipping or transport
• Store reconstituted solutions at 2–8 °C for short-term use
• For extended storage, aliquot and freeze at –20 °C or –80 °C
• Avoid repeated freeze–thaw cycles

Handle materials according to institutional laboratory biosafety protocols.

References

https://pubmed.ncbi.nlm.nih.gov/22682628/

https://academic.oup.com/edrv/article/44/5/753/7090400

https://pubmed.ncbi.nlm.nih.gov/11181549/

https://pmc.ncbi.nlm.nih.gov/articles/PMC2409634/

https://pmc.ncbi.nlm.nih.gov/articles/PMC2121039/

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.