MT-2 (Melanotan 2)

Description

Strength: 10mg
CAS: 121062-08-6
Chemical Formula: C₅₀H₆₉N₁₅O₉
Molecular weight: 1024.198 g/mol
Peptide Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Synonyms: MT-2
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

MT-2 peptide is a synthetic version of α-melanocyte-stimulating hormone (α-MSH), a naturally occurring protein involved in skin pigmentation. It is a cyclic peptide with a molecular weight of approximately 1,024 Da. MT-2 is provided as a 10 mg vial of lyophilized powder with ≥95% purity, ensuring reliability for research applications.

This peptide is commonly used in laboratory research to study skin pigmentation, melanocyte activation, and metabolic pathways. Researchers are particularly interested in its role in melanin production and its broader effects on the melanocortin receptor system. Experts often buy MT 2 for research on pigmentation, UV response, and related cellular processes.

• High Purity: ≥95% purity for reliable experimental results.
• Lyophilized Powder: Preserved in a stable, dry form for easy storage and reconstitution.
• 10 mg Vial: Convenient packaging for accurate dosing in research settings.
• Melanin Production: Primarily studied for its role in stimulating melanin synthesis in melanocytes.
• Research Focus: Used to study pigmentation, melanocortin receptor activity, and UV response in skin cells.

MT-2 is a non-selective melanocortin receptor agonist with high affinity for MC1R, which plays a key role in melanin production and skin pigmentation. It also binds to MC3R, MC4R, and MC5R, activating different physiological responses.

Researchers have studied MT-2 for its ability to:

• Stimulate melanin production in melanocytes, influencing skin pigmentation.
• Activate melanocortin receptors to study their impact on appetite regulation and metabolic pathways.
• Explore sexual function, immune modulation, and neuroendocrine signaling due to its effects on the melanocortin system.
• Investigate UV protection and skin cell stress responses, which makes it a valuable tool for photobiology and dermatology research.

MT-2 dosing varies by model and route. Human clinical studies have used 0.01–0.03 mg/kg subcutaneously, starting at 0.01 mg/kg and escalating based on response. Common research protocols typically employ 0.25–1.0 mg per injection subcutaneously, with initial doses of 250–500 µg and escalation of 0.25 mg every few days.

Animal studies have used 1 mg/kg intravenously or 20 µg/kg every 48 hours subcutaneously, depending on endpoints. Cell culture studies use nanomolar to micromolar concentrations. All dosing is experiment-specific and should be determined by the research objective, model system, and measurement endpoints.

Moreover, key observations on the MT-2 research peptide include:

• Increased melanin production and visible pigmentation changes in in vitro and animal models.
• Modulation of metabolic activity and appetite regulation due to melanocortin receptor activation.
• Effects on sexual function and immune response, especially in models testing MC4R

These findings are limited to preclinical research and do not extend to therapeutic or clinical use in humans.

To maintain the stability and integrity of MT-2, follow these storage guidelines:

• Lyophilized powder: Store at -20°C in a dry, light-protected container.
• Reconstitution: After reconstitution, store at 2–8°C and use within the designated time frame for optimal peptide activity.
• Avoid freeze-thaw cycles: To prevent degradation, avoid repeated freeze-thawing of the peptide.
• Safety precautions: Use standard laboratory safety protocols including gloves, lab coats, and eye protection when handling this peptide.

Dispose of unused material in accordance with local regulations.

References

https://pubmed.ncbi.nlm.nih.gov/11035391/

https://link.springer.com/chapter/10.1007/0-306-47384-4_25

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.0906-6705.2004.0212ar.x

https://www.sciencedirect.com/topics/medicine-and-dentistry/melanotan-ii

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.