NEXPLANON®

Description

Name: NEXPLANON®
Manufacturer: Merck
Active Substance(s): ETONOGESTREL
Strength: 68mg
Pack Size: 68mg – implant
Accessories: 1 x 68mg Implant ( 4 cm in length and 2 mm in diameter)

NEXPLANON® is a long-acting, reversible contraceptive implant containing the synthetic progestin etonogestrel. It is a small, flexible, radiopaque rod inserted subdermally into the inner upper arm, designed to offer up to three years of pregnancy prevention. The implant works by suppressing ovulation, thickening cervical mucus, and altering the endometrium. With a release rate starting at 60–70 mcg/day, declining to 25–30 mcg/day by the third year, NEXPLANON provides effective contraception without the need for daily adherence.

Healthcare professionals must be trained in the proper insertion and removal technique to avoid complications. NEXPLANON’s radiopaque feature enables X-ray visibility, aiding in the localization of misplaced or migrated implants.

• Single-rod, radiopaque contraceptive implant effective for up to 3 years
• Contains 68 mg of etonogestrel, released subdermally at a controlled rate
• Offers >99% contraceptive efficacy, independent of daily user compliance

NEXPLANON is supplied as a single-use sterile applicator containing one pre-loaded implant. The implant is 4 cm long and 2 mm in diameter, designed for subdermal insertion.

Active Ingredients:

• Etonogestrel: 68 mg, synthetic progestin and active metabolite of desogestrel
• Barium sulfate: 15 mg, for radiopacity
• Magnesium stearate: 0.1 mg, used as a stabilizer
  

Implant Core Material:

• Ethylene vinyl acetate (EVA) copolymer, encasing the active compounds in a non-biodegradable, flexible rod

The implant is free from latex and does not contain any animal-derived ingredients.

NEXPLANON is indicated for pregnancy prevention in reproductive-age women. It is highly effective due to its consistent release of etonogestrel and does not require daily use.

Contraindications:

• Known or suspected pregnancy
• Active or past thromboembolic disorders
• Liver tumors or active liver disease
• Undiagnosed abnormal genital bleeding
• Known or suspected breast cancer
• Hypersensitivity to any component of NEXPLANON
  

Common Side Effects:

• Menstrual irregularities (up to 35% with >21 bleeding days per 90-day period)
• Headache (24.9%), vaginitis (14.5%), acne (13.5%), weight gain (13.7%)
• Insertion site reactions such as erythema, bruising, or pain
• Rare but serious risks include ectopic pregnancy, thrombotic events, migration of the implant, and neurovascular injury

The implant must be inserted and removed only by trained healthcare professionals using aseptic technique. Proper placement ensures effectiveness and minimizes complications such as deep insertions or migration.

Insertion Technique:

• Location: Inner side of the non-dominant upper arm, 8–10 cm from the medial epicondyle, and 3–5 cm posterior to the sulcus
• Angle: Insertion at an angle <30°, subdermally
• Confirmation: Implant should be palpable post-insertion
• Replacement: Every 3 years, removal and reinsertion may use the same incision site

Removal Technique:

• Use palpation to locate the implant
• Make a 2 mm incision over the implant, grasp and extract using sterile forceps
• If the implant is non-palpable, imaging (e.g., X-ray or ultrasound) is required
• Removal must be complete; broken or deeply inserted implants may require surgical intervention
  

Storage:

• Store at 25°C (77°F); excursions between 15°C to 30°C (59°F to 86°F) are permitted
• Keep in original blister packaging to maintain sterility
• Do not freeze

NEXPLANON is a clinically proven contraceptive offering efficacy, discretion, and convenience, with clear safety protocols for administration, monitoring, and removal.

Warning! The product is intended solely for professional use in a medical environment and under professional supervision. The product is supplied to medical professionals who specialize in aesthetic medicine (plastic surgery, facial treatments) and work under individual medical licenses as aestheticians or in dedicated clinics. Unprofessional use by individuals without a medical background may lead to severe adverse effects and health harm.