NAD+ 500mg

Name: NAD+ 500mg
SKU: 100253
Price: 191 USD
Availability: InStock

Brand: NOVERA COMPOUNDS

Strength: 500mg
CAS: 53-84-9
Chemical Formula: C₂₁H₂₇N₇O₁₄P₂
Molecular weight: 663.43 g/mol
Synonyms: Nicotinamide adenine dinucleotide, nmn, nad
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

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$ 191.00

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NAD+ (nicotinamide adenine dinucleotide) is a naturally occurring coenzyme studied in cellular metabolism and redox biology research. Research suggests it may help support energy production, mitochondrial function, and enzyme-driven signaling pathways involved in cellular homeostasis and stress response, primarily through its role as a vital electron carrier and enzymatic cofactor.

Disclaimer : Available as lyophilized (freeze-dried) powder for laboratory and in vitro research applications. Reconstitution solution is not included in the pack.

Purity ≥99%

Made in USA

Research Use Only

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Description

NAD+ - About This Product

NAD+ (Nicotinamide adenine dinucleotide, NMN, NAD) is an essential cellular coenzyme involved in redox metabolism and energy production across all living systems. As a pyridine nucleotide cofactor, NAD+ consists of two nucleotides—adenine and nicotinamide—joined through their phosphate groups. It has a molecular formula of C₂₁H₂₇N₇O₁₄P₂ and a molecular weight of 663.43 g/mol.

CAS Number: 53-84-9

NAD+ functions as a critical electron carrier by cycling between its oxidized (NAD+) and reduced (NADH) states, enabling mitochondrial oxidative phosphorylation and glycolytic energy transfer in experimental models. This cofactor is supplied as a high-purity lyophilized powder at ≥99% purity in convenient vial formats. It is used primarily in laboratory research to investigate cellular energy metabolism, DNA repair mechanisms, and aging-related processes.

NAD+ - Key Features and Benefits

High Purity: ≥99% purity, verified by HPLC and mass-based analysis, ensuring consistent and reliable results in research
Water-Soluble: Easily reconstituted in aqueous solutions for in vitro assays and enzyme activity measurements
Multi-System Research Applications: Studied for its role in redox biochemistry, mitochondrial metabolism, and enzyme cofactor functions
DNA Repair & Cellular Stress: Investigated as a substrate for sirtuins and poly(ADP-ribose) polymerases (PARPs), enzymes critical for DNA repair and cellular stress responses
Metabolic Investigations: Used to explore glycolysis, oxidative phosphorylation, and mitochondrial energy production pathways
Aging-Associated Research: Researchers examined the NAD+ anti-aging peptide in model systems, exploring age-related changes in gene expression and metabolic regulation
Laboratory Research Use Only: Those who wish to buy NAD+ should know that it is intended strictly for controlled in vitro and preclinical research environments

NAD+ - Mechanism & Research Applications

Researchers use NAD+ with the strength of 500mg as an essential cofactor and experimental variable in multiple research contexts. NAD+ functions as a redox-active molecule capable of accepting and donating electrons in enzymatic reactions. It serves as a vital substrate for two major enzyme families involved in cellular regulation: sirtuins and poly(ADP-ribose) polymerases (PARPs).

Sirtuins use NAD+ to remove acetyl groups from protein lysine residues, influencing chromatin structure, gene expression, and DNA repair processes. PARPs use NAD+ to create ADP-ribose chains during DNA damage response, enabling the base excision repair pathway. These NAD+-dependent enzymes are central to maintaining genomic stability and managing cellular stress responses.

Key research applications include:

Cellular Energy: NAD+ cellular energy helps cells generate ATP, which is critical for various cellular functions.
Oxidative Stress Regulation: NAD+ participates in reactions that help neutralize free radicals, promoting cellular health.
DNA Repair & Cellular Aging: NAD+ is studied for its impact on sirtuins and poly(ADP-ribose) polymerases (PARPs), enzymes involved in DNA repair and aging processes.
Metabolic Regulation: NAD+ is under investigation for its role in metabolism, energy homeostasis, and immune system regulation.

All research is conducted in in vitro and preclinical models. NAD+ is not intended for clinical use or human applications.

NAD+ Dosing & Observed Effects in Research

NAD+ is typically used in laboratory research through multiple experimental approaches, each with distinct dosing parameters. In in vitro studies, researchers typically work with NAD+ concentrations ranging from 1–100 μM in cell-based assays to investigate enzyme activity, redox reactions, and metabolic readouts.

Meanwhile, preclinical animal studies show that NAD+ is generally administered at doses dependent on the research model and route of administration. Direct NAD+ administration in animal models uses varying doses (typically 10–300 mg/kg), while NAD+ precursor compounds follow different protocols.

NAD+ Precursor Studies (NR and NMN): Clinical research on NAD+ precursors reports distinct dosage ranges:

Nicotinamide Riboside (NR): 100–1000 mg daily, with most studies using 250–500 mg per day
Nicotinamide Mononucleotide (NMN): 150–1200 mg daily, with studies showing efficacy at 250–900 mg per day

Moreover, key observations from these research contexts include:

Activation of NAD+-dependent enzyme systems: Sirtuins and PARPs show increased activity with adequate NAD+ substrate availability
Improvements in mitochondrial function markers: Studies report associations between NAD+ availability and oxidative phosphorylation capacity
Shifts in gene expression profiles: Transcriptomic analyses describe differential expression patterns in NAD+-modulated experimental conditions

These findings remain within controlled experimental settings and are presented as research observations rather than clinical outcomes.

NAD+ Storage, Safety & References

Store lyophilized NAD+ at –20°C or lower in sealed, light-protected containers. Reconstituted solutions should be stored at 2–8°C and used within 7 days to maintain biochemical activity. Moreover, only room temperature during transport is acceptable. Avoid repeated freeze-thaw cycles to preserve integrity.

Follow standard laboratory safety protocols at all times. Use appropriate personal protective equipment, including gloves, a lab coat, and eye protection. Avoid exposure to light, moisture, and extreme temperatures. The product is for laboratory research use only and should not be administered to humans or animals outside authorized clinical research settings.