IGF-1 DES 1mg

Description

Strength: 1mg
CAS: 112603-35-7
Chemical Formula: C₃₁₉H₅₀₁N₉₁O₉₆S₇
Molecular weight: 7371.48 g/mol
Peptide Sequence: H-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala-OH
Synonyms: IGF1 Human Des1-3; Insulin-Like Growth Factor 1 Des (1-3) Human Recombinant; Somatomedin C; IGF-I; IGFI; IGF1; IGF-IA; Des(1-3); Des1-3; Des 1-3; Des (1-3); IGF-1 (4-70); IGF1 Des1-3
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

The IGF-1 DES peptide (also referred to as des(1–3)-IGF-1 or IGF-1 (4–70)) is a synthetic, truncated analogue of insulin-like growth factor-1 composed of 67 amino acids, with a molecular weight of 7371.48 g/mol. Laboratories that buy IGF-1 DES peptide or order IGF-1 DES peptide materials reference this compound for controlled laboratory research examining IGF signaling behavior and binding-protein interactions in experimental systems.

• CAS Number: 112603-35-7

This muscle growth and performance peptide is derived from the naturally occurring cleavage of full-length IGF-1, in which the first three N-terminal amino acids (Gly-Pro-Glu) are removed. This structural modification results in reduced affinity for insulin-like growth factor binding proteins (IGFBPs), particularly IGFBP-3, a property that has been examined in comparative cell-based research models.

The product is supplied as a lyophilized powder in 1 mg glass vials, commonly produced at >95% purity as verified by analytical testing, and intended exclusively for laboratory research use.

• Chemical Identity: Truncated IGF-1 analogue (des(1–3)-IGF-1)
• Chemical Formula: C₃₁₉H₅₀₁N₉₁O₉₆S₇
• Synonyms: IGF1 Human Des1-3; Insulin-Like Growth Factor 1 Des (1-3) Human Recombinant; Somatomedin C; IGF-I; IGFI; IGF1; IGF-IA; Des(1-3); Des1-3; Des 1-3; Des (1-3); IGF-1 (4-70); IGF1 Des1-3
• Purity: Commonly reported at >95%, verified by analytical methods
• Format: Supplied as a lyophilized powder in sterile vials
• Binding characteristics: Reduced interaction with IGF binding proteins compared with full-length IGF-1
• Research scope: Studied in laboratory models examining IGF signaling and cellular response patterns

For laboratory research use only.

IGF-1 DES has been examined in laboratory research as a bioactive IGF-1 variant evaluated for its interaction with the IGF-1 receptor under controlled experimental conditions. Due to its truncated N-terminus, the peptide demonstrates altered binding behavior relative to full-length IGF-1, which is used in research to study IGF signaling in the presence of reduced IGFBP modulation.

Research applications include:

• IGF-receptor signaling studies in cell culture systems
• Comparative binding investigations examining IGF-1 variants and IGFBP interactions
• Neuronal and metabolic cell models used for experimental signaling analysis
• Tissue-specific signaling research evaluating short-term cellular response markers

All applications described reflect controlled laboratory research contexts and do not imply clinical or therapeutic use.

Published research involving IGF-1 DES primarily reports experimental concentration ranges rather than standardized dosing protocols. In in vitro studies, the peptide is commonly evaluated at nanogram-per-milliliter concentrations, with working ranges adjusted according to cell type and assay design.

Reported laboratory observations include concentration-dependent changes in cellular signaling markers and other assay-specific molecular readouts. These findings are derived exclusively from controlled laboratory and preclinical research environments and do not establish safety, efficacy, or clinical relevance.

Researchers who order IGF-1 DES peptide materials are expected to establish experimental parameters appropriate to their specific model systems.

• Store lyophilized vials at –18 °C to –20 °C, protected from light and moisture
• Maintain vials in a desiccated environment when not in use
• Reconstitute only with sterile water, PBS, DMEM, or dilute acetic acid using aseptic technique
• Store reconstituted solutions at 2–8 °C for short-term use
• For longer storage, aliquot and freeze at –20 °C or –80 °C
• Avoid repeated freeze–thaw cycles

Handle materials in accordance with institutional laboratory biosafety protocols.

References

https://pubmed.ncbi.nlm.nih.gov/8930132/

https://pubmed.ncbi.nlm.nih.gov/10048587/

https://pmc.ncbi.nlm.nih.gov/articles/PMC10573540/

https://pmc.ncbi.nlm.nih.gov/articles/PMC3251748/

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.