GHK-Cu 100mg

Description

Strength: 100mg
CAS: 89030-95-5
Chemical Formula: C₁₄H₂₁N₆O₄Cu
Molecular weight: 401.91 g/mol
Peptide Sequence: Gly-His-Lys(Cu2+)
Synonyms: Copper peptide, GHK, Tripeptide, ghkcu, GHK-Cu acetate, Gly-His-Lys-Cu(II)
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

GHK-Cu peptide is a copper-binding tripeptide composed of glycyl-L-histidyl-L-lysine (GHK) complexed with a divalent copper ion (Cu²⁺). This peptide–metal complex occurs naturally in human biological fluids, including plasma and saliva, and has been studied for its role in cellular communication, tissue maintenance, and copper homeostasis. Endogenous levels of GHK-Cu decline with age, prompting sustained research interest in aging and regenerative biology models.

GHK-Cu (100mg) is supplied as a high-purity lyophilized powder in sterile vials and is intended exclusively for laboratory research use. Researchers who buy GHK-Cu peptide commonly utilize this format in controlled experimental environments to study extracellular matrix regulation, gene-expression modulation, copper transport mechanisms, and tissue-repair signaling in both in vitro and preclinical models.

• Research-grade purity designed to support consistent and reproducible experimental outcomes
• Stable copper–peptide complex supplied in lyophilized form
• Sterile, sealed vial packaging for controlled laboratory handling
• Extensively studied in tissue remodeling research, including connective tissue and skin models
• Compatible with cell culture systems and animal research models
• Maintains chemical and structural integrity under recommended storage conditions

GHK-Cu is studied as a bioactive signaling complex that facilitates regulated copper delivery and modulates multiple intracellular and extracellular pathways. Copper functions as an essential cofactor for enzymes involved in antioxidant defense, energy metabolism, angiogenesis, and connective tissue formation. When complexed with GHK, copper uptake appears to be more tightly regulated at the cellular level, making the peptide suitable for mechanistic research.

Researchers who order GHK-Cu peptide commonly investigate its role in the following experimental contexts:

• Extracellular Matrix Regulation: Studied for its influence on collagen, elastin, and glycosaminoglycan synthesis in connective tissue models
• Wound-Repair Signaling: Examined for effects on fibroblast activity, angiogenic signaling, and matrix remodeling under controlled injury models
• Gene-Expression Modulation: Used in transcriptomic studies evaluating changes in genes related to inflammation, oxidative stress response, and cellular growth regulation

Additional investigations explore GHK-Cu interactions with metalloproteinases and antioxidant enzymes, supporting broader research into tissue homeostasis and regenerative biology.

All dosing information for GHK-Cu peptide is derived strictly from experimental and preclinical research, with protocols varying by study design, model system, and delivery method.

• In vitro studies commonly apply micromolar concentrations to assess cellular proliferation, migration, and gene-expression responses
• Animal research models employ dose-adjusted administration to evaluate localized and systemic biological effects

Reported Research Observations

• Altered expression of genes involved in tissue repair and matrix organization
• Modulation of inflammatory mediators and oxidative stress markers
• Enhanced cellular migration and remodeling activity in experimental systems

There are no standardized dosing guidelines, and no approved clinical safety or efficacy data for human use. All findings should be interpreted strictly within controlled laboratory research frameworks.

For laboratories planning to buy GHK-Cu peptide, proper storage and handling are essential to maintain compound integrity and ensure reliable results:

• Unreconstituted: Store lyophilized powder at –20°C, protected from light and moisture
• After reconstitution: Store at 2–8°C and use within a protocol-defined timeframe
• Avoid repeated freeze–thaw cycles to preserve peptide–copper complex stability
• Handle using aseptic laboratory techniques and appropriate personal protective equipment
• Dispose of unused material in accordance with institutional and regulatory guidelines

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/

https://pmc.ncbi.nlm.nih.gov/articles/PMC3359723/

https://onlinelibrary.wiley.com/doi/10.1155/2015/648108

https://pmc.ncbi.nlm.nih.gov/articles/PMC5332963/

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1551843/full

Compliance Notice

This product is intended for laboratory research use only. It is not approved for human or veterinary use, and no clinical claims regarding safety or efficacy are made. All applications should comply with applicable laws, institutional policies, and ethical research standards.