DSIP 5mg

Description

Strength: 5mg
CAS: 62568-57-4
Chemical Formula: C₃₅H₄₈N₁₀O₁₅
Molecular weight: 848.8 g/mol
Peptide Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Synonyms: Emideltide, Delta sleep-inducing peptide
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide consisting of nine amino acids with a molecular weight of approximately 850 Da (0.85 kDa) and a molecular formula of C₃₅H₄₈N₁₀O₁₅. It is being actively researched for its effects on circadian rhythm and autonomic balance. DSIP is supplied as a lyophilized powder in sterile vials for laboratory research use. This peptide is commonly used to study neurobiological pathways, sleep-wake cycles, and stress adaptation in preclinical models.

• High purity (>95%) lyophilized powder for consistent research results.
• Provided in sealed vials, ready for reconstitution.
• Facilitates research on circadian rhythm, autonomic regulation, and neuroendocrine signaling.
• Compatible with various animal models and in vitro studies.
• Stable under long-term storage at –20°C; refrigerate after reconstitution and use promptly.

Experts are using DSIP for research for its role in sleep regulation, stress adaptation, and neuroendocrine signaling.

• Sleep Modulation: DSIP has been explored for its potential to influence sleep-wake cycles and promote sleep recovery in preclinical models.
• Stress Response: Investigated for its potential to modulate stress-related neurochemical signaling.
• Neuroendocrine Function: Studied for its effects on hormone signaling, neurotransmitter balance, and autonomic system regulation.

Additionally, DSIP may modulate glutamatergic signaling through NMDA and AMPA receptors, which are important in memory, stress response, and circadian regulation. Research suggests DSIP co-localizes with multiple hormonal mediators in the pituitary, including ACTH, TSH, and melanin-concentrating hormone, indicating broader regulatory functions beyond sleep promotion.

These studies aim to clarify how DSIP can impact neurobiological processes and circadian rhythm stability in controlled research environments.

Scientific literature reports DSIP dosing exclusively from preclinical studies.

• Rodent studies have documented effective doses at 1 mg/kg intraperitoneally, which produced significant circadian rhythm and pain threshold effects.
• Intracerebroventricular infusion studies employed much smaller microgram-range doses directly to brain tissue.
• Human clinical trials have used intravenous infusions, though specific dosing protocols varied across studies and produced mixed results for insomnia treatment.

DSIP demonstrates rapid in vitro degradation with a half-life of approximately 15 minutes when exposed to enzymatic activity, suggesting that the peptide may require carrier protein binding in vivo for stability and extended duration of action.

Observed effects include:

• Regulation of sleep-wake cycles and circadian rhythm.
• Modulation of stress-related neurotransmitters and signaling pathways.
• Impact on neuroendocrine activity and autonomic balance.

These effects have been observed in preclinical studies, with no clinical data available on human safety or efficacy. There are also no established or standardized dosing guidelines, and all dosing parameters should be considered strictly within the context of controlled research protocols.

• Store lyophilized DSIP at –20°C, protected from light and moisture.
• After reconstitution, store at 2–8°C and use promptly to preserve biological activity.
• Handle with aseptic techniques, wearing personal protective equipment (PPE), including gloves and a lab coat.
• Avoid multiple freeze-thaw cycles and dispose of unused material according to local regulations.

References

https://pubmed.ncbi.nlm.nih.gov/568769/

https://pubmed.ncbi.nlm.nih.gov/6548967/

https://pubmed.ncbi.nlm.nih.gov/3286557/

https://link.springer.com/article/10.1023/A:1016679208936

https://www.sciencedirect.com/topics/neuroscience/delta-sleep-inducing-peptide

Compliance Notice

This product is for laboratory research use only and is not approved for human or veterinary use.